Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945

Deep mutational scanning reveals EGFR mutations conferring resistance to the 4th-generation EGFR tyrosine kinase inhibitor BLU-945

Abstract Fourth-generation EGFR tyrosine kinase are in development to overcome common resistance mutations. We performed deep mutational scanning (DMS) of the EGFR kinase domain in the context of L858R by introducing a saturation library of ~17,000 variants into Ba/F3 cells. DMS library-expressing c...

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Main Authors: Yueyang Wang, Yuan Hao, Michela Ranieri, Tigran M. Abramyan, Lev Tsidilkovski, Michelle Hollenberg, Alfonso Lopez, Xavier T. R. Moore, Fiona Sherman, Jiehui Deng, Hayk Saribekyan, Garegin Papoian, Kwok-Kin Wong, Elaine Shum, John T. Poirier
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-01086-2
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https://doi.org/10.1038/s41698-025-01086-2

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