Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study
Osteoarthritis (OA) is a major source of chronic pain and disability, representing a significant global health concern that affects 10–15 % of individuals aged over 60, with a higher prevalence among females than males. This investigation aimed to evaluate the impact of a dietary supplement containi...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Contemporary Clinical Trials Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451865424001716 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841545485046775808 |
|---|---|
| author | Juan Antonio Carrillo-Norte Guillermo Gervasini-Rodríguez María Ángeles Santiago-Triviño Virginio García-López Rafael Guerrero-Bonmatty |
| author_facet | Juan Antonio Carrillo-Norte Guillermo Gervasini-Rodríguez María Ángeles Santiago-Triviño Virginio García-López Rafael Guerrero-Bonmatty |
| author_sort | Juan Antonio Carrillo-Norte |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a major source of chronic pain and disability, representing a significant global health concern that affects 10–15 % of individuals aged over 60, with a higher prevalence among females than males. This investigation aimed to evaluate the impact of a dietary supplement containing collagen peptides (MW 1–3 kDa) on knee OA symptoms and inflammatory biomarkers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Adults aged 30–81 years (50 % female) with grade II or III OA and a minimum pain score of 40 on the 0 to 100 visual analogue scale (VAS) were enrolled. Participants were randomly assigned to receive either 10 g of the test product (verum group) or placebo and were assessed at baseline (T0, pre-treatment) and after a six-month follow-up period (T6). Baseline characteristics were comparable between groups. At T6, the verum group exhibited significant reductions in VAS pain scores, Lequesne algofunctional index (LAI) scores, CRP levels (mg/L), and ESR (mm/h) compared to placebo (p < 0.001). No adverse effects were reported during the study, and the supplement demonstrated good tolerability and yielded satisfactory safety and acceptability. These findings suggest that the dietary supplement may serve as a complement to drug therapy for knee OA by alleviating osteoarticular pain, improving locomotor function and potentially reducing reliance on analgesic and anti-inflammatory medications. This study provides valuable insights into the efficacy and safety of collagen peptides in managing knee OA symptoms. |
| format | Article |
| id | doaj-art-11326b56b9164f9b9c832be741d6ee2c |
| institution | Kabale University |
| issn | 2451-8654 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Contemporary Clinical Trials Communications |
| spelling | doaj-art-11326b56b9164f9b9c832be741d6ee2c2025-01-12T05:25:31ZengElsevierContemporary Clinical Trials Communications2451-86542025-02-0143101424Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled studyJuan Antonio Carrillo-Norte0Guillermo Gervasini-Rodríguez1María Ángeles Santiago-Triviño2Virginio García-López3Rafael Guerrero-Bonmatty4Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, School of Medicine, University of Extremadura, Badajoz, Spain; Corresponding author.Department of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, School of Medicine, University of Extremadura, Badajoz, SpainIntensive Care Unit, University Hospital of Badajoz, SpainDepartment of Medical and Surgical Therapeutics, Division of Clinical Pharmacology, School of Medicine, University of Extremadura, Badajoz, SpainDepartment of Nursing, School of Nursing, University of Extremadura, Mérida, SpainOsteoarthritis (OA) is a major source of chronic pain and disability, representing a significant global health concern that affects 10–15 % of individuals aged over 60, with a higher prevalence among females than males. This investigation aimed to evaluate the impact of a dietary supplement containing collagen peptides (MW 1–3 kDa) on knee OA symptoms and inflammatory biomarkers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Adults aged 30–81 years (50 % female) with grade II or III OA and a minimum pain score of 40 on the 0 to 100 visual analogue scale (VAS) were enrolled. Participants were randomly assigned to receive either 10 g of the test product (verum group) or placebo and were assessed at baseline (T0, pre-treatment) and after a six-month follow-up period (T6). Baseline characteristics were comparable between groups. At T6, the verum group exhibited significant reductions in VAS pain scores, Lequesne algofunctional index (LAI) scores, CRP levels (mg/L), and ESR (mm/h) compared to placebo (p < 0.001). No adverse effects were reported during the study, and the supplement demonstrated good tolerability and yielded satisfactory safety and acceptability. These findings suggest that the dietary supplement may serve as a complement to drug therapy for knee OA by alleviating osteoarticular pain, improving locomotor function and potentially reducing reliance on analgesic and anti-inflammatory medications. This study provides valuable insights into the efficacy and safety of collagen peptides in managing knee OA symptoms.http://www.sciencedirect.com/science/article/pii/S2451865424001716Collagen peptidesDietary supplementKnee osteoarthritisJoint painJoint functional limitation |
| spellingShingle | Juan Antonio Carrillo-Norte Guillermo Gervasini-Rodríguez María Ángeles Santiago-Triviño Virginio García-López Rafael Guerrero-Bonmatty Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study Contemporary Clinical Trials Communications Collagen peptides Dietary supplement Knee osteoarthritis Joint pain Joint functional limitation |
| title | Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study |
| title_full | Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study |
| title_fullStr | Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study |
| title_full_unstemmed | Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study |
| title_short | Oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis: Results from a randomized, double-blind, placebo-controlled study |
| title_sort | oral administration of hydrolyzed collagen alleviates pain and enhances functionality in knee osteoarthritis results from a randomized double blind placebo controlled study |
| topic | Collagen peptides Dietary supplement Knee osteoarthritis Joint pain Joint functional limitation |
| url | http://www.sciencedirect.com/science/article/pii/S2451865424001716 |
| work_keys_str_mv | AT juanantoniocarrillonorte oraladministrationofhydrolyzedcollagenalleviatespainandenhancesfunctionalityinkneeosteoarthritisresultsfromarandomizeddoubleblindplacebocontrolledstudy AT guillermogervasinirodriguez oraladministrationofhydrolyzedcollagenalleviatespainandenhancesfunctionalityinkneeosteoarthritisresultsfromarandomizeddoubleblindplacebocontrolledstudy AT mariaangelessantiagotrivino oraladministrationofhydrolyzedcollagenalleviatespainandenhancesfunctionalityinkneeosteoarthritisresultsfromarandomizeddoubleblindplacebocontrolledstudy AT virginiogarcialopez oraladministrationofhydrolyzedcollagenalleviatespainandenhancesfunctionalityinkneeosteoarthritisresultsfromarandomizeddoubleblindplacebocontrolledstudy AT rafaelguerrerobonmatty oraladministrationofhydrolyzedcollagenalleviatespainandenhancesfunctionalityinkneeosteoarthritisresultsfromarandomizeddoubleblindplacebocontrolledstudy |