ERCC6L-mediated stabilization of HIF-1α enhances glycolysis and stemness properties of lung adenocarcinoma cells

Abstract Molecular signatures are increasingly recognized as pivotal factors in therapy selection for lung adenocarcinomas (LUAD). A developing therapeutic approach focuses on targeting metabolic dependencies within cancer cells. ERCC6L, a vital protein involved in chromosome separation during cell...

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Bibliographic Details
Main Authors: Zhimin Lu, Xuming Yao, Jialu Jiang, Guoxin Hou
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07879-4
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