Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells

Position in proton Bragg curve influences DNA damage complexity and survival in head and neck cancer cells

Background and purpose: Understanding the cellular and molecular effect of proton radiation, particularly the increased DNA damage complexity at the distal end of the Bragg curve, is current topic of investigation. This work aims to study in vitro clonogenic survival and DNA damage foci kinetics of...

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Bibliographic Details
Main Authors: Tim Heemskerk, Celebrity Groenendijk, Marta Rovituso, Ernst van der Wal, Wouter van Burik, Konstantinos Chatzipapas, Danny Lathouwers, Roland Kanaar, Jeremy M.C. Brown, Jeroen Essers
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Proton therapy
DNA Breaks, Double-stranded
Squamous cell carcinoma of head and neck
DNA damage
Linear energy transfer
Radiobiology
Online Access:http://www.sciencedirect.com/science/article/pii/S240563082400185X
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