Generation of mature epicardium derived from human-induced pluripotent stem cells via inhibition of mTOR signaling

Generation of mature epicardium derived from human-induced pluripotent stem cells via inhibition of mTOR signaling

Abstract Reactivating the human epicardium post-cardiac injury holds promise for cardiac tissue regeneration. Despite successful differentiation protocols yielding pure, self-renewing epicardial cells from induced pluripotent stem cells (iPSCs), these cells maintain an embryonic, proliferative state...

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Main Authors: Yu Tian, Antonio Lucena-Cacace, Kanae Tani, Amanda Putri Elvandari, Rodolfo S. Allendes Osorio, Megumi Narita, Yasuko Matsumura, Ian Costa Paixao, Yutaro Miyoshi, Azusa Inagaki, Julia Junghof, Yoshinori Yoshida
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60934-8
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