SHP2 inhibition by SHP099 attenuates IL-6–driven osteoclastogenesis in growth plate injury

SHP2 inhibition by SHP099 attenuates IL-6–driven osteoclastogenesis in growth plate injury

IntroductionDisruption of growth plate cartilage often leads to severe bone growth defects in children, necessitating novel therapeutic strategies. Following growth plate injury, an inflammatory response is rapidly initiated, resulting in the release of pro-inflammatory cytokines such as IL-6 into t...

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Bibliographic Details
Main Authors: Qin Zhang, Ning Li, Zhen-Zhen Dai, Xiao-Man Liu, Jing Ding, Lin Sha, Hai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
SHP2
SHP099
IL-6
osteoclasts
growth plate injury
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1659230/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1659230/full

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