Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis

Galactin-8 DNA methylation mediates macrophage autophagy through the MAPK/mTOR pathway to alleviate atherosclerosis

Abstract DNA methylation modifications are an important mechanism affecting the process of atherosclerosis (AS). Previous studies have shown that Galectin-8 (GAL8) DNA methylation level is associated with sudden death of coronary heart disease or acute events of coronary heart disease. However, the...

Full description

Saved in:

Bibliographic Details
Main Authors:	Bing Xia, Yan-lin Lu, Jin Peng, Jing-wei Liang, Fang-qin Li, Jiu-yang Ding, Chang-wu Wan, Cui-yun Le, Jia-lin Dai, Jie-Wang, Bing Guo, Jiang Huang
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-01-01
Series:	Scientific Reports
Subjects:	Coronary heart disease GAL-8 promoter methylation MAPK/mTOR signaling Pathway Atherosclerosis
Online Access:	https://doi.org/10.1038/s41598-024-85036-1
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Bone marrow mesenchymal stem cell-derived extracellular vesicles alleviate diabetes-exacerbated atherosclerosis via AMPK/mTOR pathway-mediated autophagy-related macrophage polarization
by: Libo Liu, et al.
Published: (2025-01-01)

ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer
by: Bo Shi, et al.
Published: (2025-01-01)

Molecular mechanisms of mTOR-mediated cisplatin response in tumor cells
by: Amirhosein Maharati, et al.
Published: (2025-01-01)

Porphyra haitanensis polysaccharide (PH) attenuates cell hyperplasia via remodeling the cross-talk between Hippo/YAP and mTOR pathways
by: Chong Wang, et al.
Published: (2023-03-01)

AKT/mTOR信号通路在喉癌组织中的表达及意义
Published: (2009-01-01)

Reactivation of mTOR signaling slows neurodegeneration in a lysosomal sphingolipid storage disease
by: Hongling Zhu, et al.
Published: (2025-01-01)

Apigenin suppresses osteoarthritis progression by inhibiting pyroptosis via SIRT1/mTOR pathway-mediated mitophagy
by: Jiahao Ying, et al.
Published: (2025-01-01)

Bifidobacterium breve BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway
by: Yanni Pan, et al.
Published: (2025-01-01)

Lingguizhugan decoction enhances autophagy of Alzheimer’s disease via regulating the mTOR/ p70s6K pathway in vivo and in vitro
by: Xiaojing Chen, et al.
Published: (2025-01-01)

Assessments of prostate cancer cell functions highlight differences between a pan‐PI3K/mTOR inhibitor, gedatolisib, and single‐node inhibitors of the PI3K/AKT/mTOR pathway
by: Adrish Sen, et al.
Published: (2025-01-01)

FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease
by: Xuelin He, et al.
Published: (2025-02-01)

Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice
by: Gabriela Xavier Santos, et al.
Published: (2025-01-01)

Mechanism of mTOR/RILP-regulated autophagic flux in increased susceptibility to myocardial ischemia-reperfusion in diabetic mice
by: Jiyao Zhao, et al.
Published: (2025-01-01)

A novel sensitizer reduces EGFR-TKI resistance by regulating the PI3K/Akt/mTOR pathway and autophagy
by: Jue Zhang, et al.
Published: (2025-01-01)

不同时期高蛋白营养干预对宫内生长受限大鼠体成分和骨骼肌ｍＴＯＲ活性的影响
Published: (2012-01-01)

Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer
by: Jingyang Li, et al.
Published: (2025-02-01)

Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors
by: Anna Hernández‐Prat, et al.
Published: (2025-01-01)

Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation
by: Feng Wang, et al.
Published: (2025-01-01)

mTOR downregulation promotes anti-inflammatory responses via the CCL3-CCR5 axis in hypoxic retinopathy
by: Tae Kwon Moon, et al.
Published: (2025-03-01)

Corticosterone-induced postpartum depression induces depression-like behavior and impairs hippocampal neurogenesis in adolescent offspring via HPA axis and BDNF-mTOR pathway
by: Hongxiao Xie, et al.
Published: (2025-01-01)

<i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells
by: Yujing Xie, et al.
Published: (2025-01-01)

DRAM1 enhances the proliferation and metastasis of gastric cancer through the PI3K/AKT/mTOR signaling pathway and energy metabolism
by: Xinrong Wu, et al.
Published: (2025-01-01)

Ginsenoside Rg1 alleviates chronic testicular damage caused by cranial irradiation through the SCF/PI3K/Akt/mTOR pathway in mice
by: Qiuhua Zhou, et al.
Published: (2025-02-01)

Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathway-mediated Th1 differentiation
by: Shun Xu, et al.
Published: (2025-01-01)

Studying the impact of chitosan salicylaldehyde/schiff base/CuFe2O4 in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling
by: Ghada H. Elsayed, et al.
Published: (2025-02-01)

Long-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized, observer-blind, controlled phase IIb national multicentre clinical trial: study protocol
by: Jan H. Driedger, et al.
Published: (2025-01-01)

Mechanism of podophyllotoxin-induced ovarian toxicity via the AMPK/TSC1/mTOR/ULK1 axis in rats on the basis of toxicological evidence chain (TEC) concept
by: Jingjing Li, et al.
Published: (2025-01-01)

AMPK: An energy sensor for non-small cell lung cancer progression and treatment
by: Zhi-Ting Zhong, et al.
Published: (2025-02-01)

Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex
by: Jason S. Hauptman, et al.
Published: (2025-01-01)

Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models
by: Andrea Mancini, et al.
Published: (2022-11-01)

Corrigendum: Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models
by: Andrea Mancini, et al.
Published: (2025-01-01)

人参皂苷Rb1抗小鼠脑自然衰老及其对mTOR/p70S6K 通路的影响
Published: (2015-01-01)

GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway
by: Chenhua Luo, et al.
Published: (2025-01-01)

α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach
by: Aimin Cai, et al.
Published: (2025-01-01)

磷酸化的哺乳动物雷帕霉素靶蛋白在胃癌组织中的表达
Published: (2009-01-01)

The role and underlying mechanism of dental pulp stem cell-derived exosomal miR-31 in the treatment of osteoarthritis by targeting mTOR to enhance chondrocyte autophagy levels
by: Guanglei Zhao, et al.
Published: (2023-01-01)

Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway
by: Xiaomei Zhong, et al.
Published: (2025-01-01)

Protective Effect of Exercise Preconditioning on Myocardial Ischemia-Reperfusion Injury in Rats Based on Autophagy
by: Qiang TANG, et al.
Published: (2019-10-01)

Rapamycin inhibits tamoxifen-induced endometrial proliferation in vitro as a pilot approach for endometrial protection in breast cancer
by: Akiko Nakamura, et al.
Published: (2025-01-01)

Sulforaphane acutely activates multiple starvation response pathways
by: Kendra S. Plafker, et al.
Published: (2025-01-01)