High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

High‐throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts

Abstract Mutations in OPA1 cause autosomal dominant optic atrophy (DOA) as well as DOA+, a phenotype characterized by more severe neurological deficits. OPA1 deficiency causes mitochondrial fragmentation and also disrupts cristae, respiration, mitochondrial DNA (mtDNA) maintenance, and cell viabilit...

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Bibliographic Details
Main Authors: Emma Cretin, Priscilla Lopes, Elodie Vimont, Takashi Tatsuta, Thomas Langer, Anastasia Gazi, Martin Sachse, Patrick Yu‐Wai‐Man, Pascal Reynier, Timothy Wai
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
genetic modifiers
high‐throughput screening
mitochondrial dynamics
OPA1
phospholipid metabolism
Online Access:https://doi.org/10.15252/emmm.202013579
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https://doi.org/10.15252/emmm.202013579

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