Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction

Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction

Abstract Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to presti...

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Main Authors: Frédérique Kok, Marcus Rosenblatt, Melissa Teusel, Tamar Nizharadze, Vladimir Gonçalves Magalhães, Christopher Dächert, Tim Maiwald, Artyom Vlasov, Marvin Wäsch, Silvana Tyufekchieva, Katrin Hoffmann, Georg Damm, Daniel Seehofer, Tobias Boettler, Marco Binder, Jens Timmer, Marcel Schilling, Ursula Klingmüller
Format: Article
Language:English
Published: Springer Nature 2020-07-01
Series:Molecular Systems Biology
Subjects:
dynamic pathway modeling
feedback control
interferon
personalized treatment
signal transduction
Online Access:https://doi.org/10.15252/msb.20198955
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https://doi.org/10.15252/msb.20198955

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