Hepatitis surface B antigen clearance induced by long-term tenofovir disoproxil fumarate monotherapy in chronic hepatitis B treatment: a meta-analysis and longitudinal modeling analysis

Hepatitis surface B antigen clearance induced by long-term tenofovir disoproxil fumarate monotherapy in chronic hepatitis B treatment: a meta-analysis and longitudinal modeling analysis

Abstract Background Chronic hepatitis B (CHB) is a significant global health challenge, with tenofovir disoproxil fumarate (TDF) widely used as an effective treatment option. Despite TDF’s efficacy in suppressing hepatitis B virus (HBV) DNA, it rarely achieves functional cure, requiring hepatitis B...

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Bibliographic Details
Main Authors: Weizhe Jian, Yalin Yin, Junsheng Xue, Rong Chen, Jingwen Feng, Jiayao Zeng, Ruoyi He, Tianyan Zhou
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Virology Journal
Subjects:
CHB
TDF
HBsAg clearance
HBsAg seroconversion
Model-based simulation
Online Access:https://doi.org/10.1186/s12985-025-02788-6
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https://doi.org/10.1186/s12985-025-02788-6

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