A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia
The occurrence of acute myeloid leukemia (AML) within six months from a diagnosis of breast cancer (BC) is rarely reported in the literature, and it is associated with a poor prognosis. We report herein the case of a 40-year-old woman referred to our centre affected by BC and simultaneous AML. The p...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8893185 |
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| author | L. Ballotta S. M. Trisolini A. P. Iori U. La Rocca A. Micozzi G. Gentile T. De Giacomo A. Guarini R. Foà S. Capria |
| author_facet | L. Ballotta S. M. Trisolini A. P. Iori U. La Rocca A. Micozzi G. Gentile T. De Giacomo A. Guarini R. Foà S. Capria |
| author_sort | L. Ballotta |
| collection | DOAJ |
| description | The occurrence of acute myeloid leukemia (AML) within six months from a diagnosis of breast cancer (BC) is rarely reported in the literature, and it is associated with a poor prognosis. We report herein the case of a 40-year-old woman referred to our centre affected by BC and simultaneous AML. The patient proved refractory to first line therapy and achieved complete remission (CR) with a clofarabine-based regimen followed by allogeneic stem cell transplantation (ASCT). Both during salvage chemotherapy and after ASCT, the patient presented severe infectious complications ( acute cholecistytis and Nocardia pneumonia, respectively) treated with surgery, and currently she is alive in CR for both diseases after 29 months of follow-up. The case highlights the importance of a diagnostic assessment of any unexplained cytopenia in association with solid neoplasia under treatment, underlining the feasibility and priority of a timely treatment of the haematological neoplasm in order to achieve long-term survival. |
| format | Article |
| id | doaj-art-0f31d9e5f7ab4d0e95b4dfd8098e98f4 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-0f31d9e5f7ab4d0e95b4dfd8098e98f42025-08-20T03:55:44ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/88931858893185A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid LeukemiaL. Ballotta0S. M. Trisolini1A. P. Iori2U. La Rocca3A. Micozzi4G. Gentile5T. De Giacomo6A. Guarini7R. Foà8S. Capria9Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyDepartment of Cardiovascular and Thoracic Surgery “Paride Stefanini”, Sapienza University, Policlinico Umberto I, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyHematology, Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyThe occurrence of acute myeloid leukemia (AML) within six months from a diagnosis of breast cancer (BC) is rarely reported in the literature, and it is associated with a poor prognosis. We report herein the case of a 40-year-old woman referred to our centre affected by BC and simultaneous AML. The patient proved refractory to first line therapy and achieved complete remission (CR) with a clofarabine-based regimen followed by allogeneic stem cell transplantation (ASCT). Both during salvage chemotherapy and after ASCT, the patient presented severe infectious complications ( acute cholecistytis and Nocardia pneumonia, respectively) treated with surgery, and currently she is alive in CR for both diseases after 29 months of follow-up. The case highlights the importance of a diagnostic assessment of any unexplained cytopenia in association with solid neoplasia under treatment, underlining the feasibility and priority of a timely treatment of the haematological neoplasm in order to achieve long-term survival.http://dx.doi.org/10.1155/2020/8893185 |
| spellingShingle | L. Ballotta S. M. Trisolini A. P. Iori U. La Rocca A. Micozzi G. Gentile T. De Giacomo A. Guarini R. Foà S. Capria A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia Case Reports in Hematology |
| title | A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia |
| title_full | A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia |
| title_fullStr | A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia |
| title_full_unstemmed | A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia |
| title_short | A Rare Case of Coexisting Breast Cancer and Refractory Acute Myeloid Leukemia |
| title_sort | rare case of coexisting breast cancer and refractory acute myeloid leukemia |
| url | http://dx.doi.org/10.1155/2020/8893185 |
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