Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract

Lactobacillus crispatus S-layer proteins modulate innate immune response and inflammation in the lower female reproductive tract

Abstract Lactobacillus species dominance of the vaginal microbiome is a hallmark of vaginal health. Pathogen displacement of vaginal lactobacilli drives innate immune activation and mucosal barrier disruption, increasing the risks of STI acquisition and, in pregnancy, of preterm birth. We describe d...

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Main Authors: Alexiane Decout, Ioannis Krasias, Lauren Roberts, Belen Gimeno Molina, Chloé Charenton, Daniel Brown Romero, Qiong Y. Tee, Julian R. Marchesi, Sherrianne Ng, Lynne Sykes, Phillip R. Bennett, David A. MacIntyre
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55233-7
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https://doi.org/10.1038/s41467-024-55233-7

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