VEGFA activates an epigenetic pathway upregulating ovarian cancer‐initiating cells

Abstract The angiogenic factor, VEGFA, is a therapeutic target in ovarian cancer (OVCA). VEGFA can also stimulate stem‐like cells in certain cancers, but mechanisms thereof are poorly understood. Here, we show that VEGFA mediates stem cell actions in primary human OVCA culture and OVCA lines via VEG...

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Bibliographic Details
Main Authors: Kibeom Jang, Minsoon Kim, Candace A Gilbert, Fiona Simpkins, Tan A Ince, Joyce M Slingerland
Format: Article
Language:English
Published: Springer Nature 2017-02-01
Series:EMBO Molecular Medicine
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Online Access:https://doi.org/10.15252/emmm.201606840
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