Promising therapeutic efficacy and safety of a novel integrin α6-targeting peptide-drug conjugate in lung adenocarcinoma

Promising therapeutic efficacy and safety of a novel integrin α6-targeting peptide-drug conjugate in lung adenocarcinoma

Abstract Background Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, with poor prognosis due to rapid tumor growth and resistance to current treatments. Thus, the identification of novel biomarkers and therapeutic strategies has become increasingly important in the management...

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Main Authors: Wuyou Gao, Qiaoli Wang, Shibing Li, Wanqi Chen, Bin Luo, Kaili Xie, Huaze Liao, Leqi Zhong, Youfang Chen, Zhesheng Wen, Guokai Feng
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
Lung adenocarcinoma
Peptide-drug conjugate
Integrin α6
RWYD-MMAE
Targeted therapy
Online Access:https://doi.org/10.1186/s12943-025-02395-7
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https://doi.org/10.1186/s12943-025-02395-7

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