Induction treatments with and without addition of one dose anthracycline to all-trans retinoid acid and arsenic in pediatric non-high-risk acute promyelocytic leukemia: study protocol for a randomized controlled trial

Induction treatments with and without addition of one dose anthracycline to all-trans retinoid acid and arsenic in pediatric non-high-risk acute promyelocytic leukemia: study protocol for a randomized controlled trial

Abstract Background The treatment of all-trans retinoic acid (ATRA) and arsenical agent has revolutionarily improved the prognosis of acute promyelocytic leukemia (APL) both in adults and children. Nevertheless, coagulation disorder and differentiation syndrome (DS) are the main causes of early deat...

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Main Authors: Zhong Fan, Xiu-Ya Huang, Dan-Ping Huang, Jie-Si Luo, Jia-Yin Su, Xiao-Li Zhang, Yu Li, Li-Na Wang, Cong Liang, Xue-Qun Luo, Li-Bin Huang, Yan-Lai Tang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Trials
Subjects:
Acute promyelocytic leukemia
Children
Arsenic trioxide
Realgar-Indigo naturalis formula
Chemotherapy
Online Access:https://doi.org/10.1186/s13063-024-08664-y
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https://doi.org/10.1186/s13063-024-08664-y

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