Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review
Endometrial carcinoma is one of the important health issues addressed globally. Therefore, understanding the molecular pathogenesis of endometrial carcinoma for the purpose of prognostic and predictive markers remains in the centre of research. It has been reported in recently published literature t...
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JCDR Research and Publications Private Limited
2025-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/20482/75346_CE[Ra1]_F(SHU)_QC(SD_SS)_PF1(AG_OM)_PFA(SS)_PB(AG_IS)_PN(IS).pdf |
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| _version_ | 1841527582011424768 |
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| author | Garima Chandrakar Arvind Bhake |
| author_facet | Garima Chandrakar Arvind Bhake |
| author_sort | Garima Chandrakar |
| collection | DOAJ |
| description | Endometrial carcinoma is one of the important health issues addressed globally. Therefore, understanding the molecular pathogenesis of endometrial carcinoma for the purpose of prognostic and predictive markers remains in the centre of research. It has been reported in recently published literature that loss of Phosphatase and Tensin Homolog (PTEN) expression, a tumour suppressor gene, is one of the key events in the pathogenesis of endometrial carcinoma. This review aims to study the data for loss of PTEN expression in literature. Based on the inclusion and exclusion criteria, eight studies were finally included in the review. Comparative statistics of various studies showed that loss of PTEN expression is a key molecular event in endometrial carcinoma. The detection of lost PTEN expression could help in knowing the progressive nature of Atypical Endometrial Hyperplasia (AEH) and in distinguishing AEH from endometrial carcinoma. This will facilitate the choice of targeted therapy. |
| format | Article |
| id | doaj-art-0ea5e423f6ac46349dcdb97bfbd74db2 |
| institution | Kabale University |
| issn | 2249-782X 0973-709X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj-art-0ea5e423f6ac46349dcdb97bfbd74db22025-01-15T11:45:05ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2025-01-011901050710.7860/JCDR/2025/75346.20482Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative ReviewGarima Chandrakar0Arvind Bhake1Junior Resident, Department of Pathology, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra, India.Director Professor, Department of Pathology, Jawaharlal Nehru Medical College, Sawangi Meghe, Wardha, Maharashtra, India.Endometrial carcinoma is one of the important health issues addressed globally. Therefore, understanding the molecular pathogenesis of endometrial carcinoma for the purpose of prognostic and predictive markers remains in the centre of research. It has been reported in recently published literature that loss of Phosphatase and Tensin Homolog (PTEN) expression, a tumour suppressor gene, is one of the key events in the pathogenesis of endometrial carcinoma. This review aims to study the data for loss of PTEN expression in literature. Based on the inclusion and exclusion criteria, eight studies were finally included in the review. Comparative statistics of various studies showed that loss of PTEN expression is a key molecular event in endometrial carcinoma. The detection of lost PTEN expression could help in knowing the progressive nature of Atypical Endometrial Hyperplasia (AEH) and in distinguishing AEH from endometrial carcinoma. This will facilitate the choice of targeted therapy.https://jcdr.net/articles/PDF/20482/75346_CE[Ra1]_F(SHU)_QC(SD_SS)_PF1(AG_OM)_PFA(SS)_PB(AG_IS)_PN(IS).pdfatypical endometrial hyperplasiaimmunohistochemistrytumour suppressor gene |
| spellingShingle | Garima Chandrakar Arvind Bhake Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review Journal of Clinical and Diagnostic Research atypical endometrial hyperplasia immunohistochemistry tumour suppressor gene |
| title | Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review |
| title_full | Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review |
| title_fullStr | Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review |
| title_full_unstemmed | Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review |
| title_short | Loss of PTEN Immunoexpression in Endometrial Carcinoma: A Narrative Review |
| title_sort | loss of pten immunoexpression in endometrial carcinoma a narrative review |
| topic | atypical endometrial hyperplasia immunohistochemistry tumour suppressor gene |
| url | https://jcdr.net/articles/PDF/20482/75346_CE[Ra1]_F(SHU)_QC(SD_SS)_PF1(AG_OM)_PFA(SS)_PB(AG_IS)_PN(IS).pdf |
| work_keys_str_mv | AT garimachandrakar lossofptenimmunoexpressioninendometrialcarcinomaanarrativereview AT arvindbhake lossofptenimmunoexpressioninendometrialcarcinomaanarrativereview |