Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Adaptive resistance of melanoma cells to RAF inhibition via reversible induction of a slowly dividing de‐differentiated state

Abstract Treatment of BRAF‐mutant melanomas with MAP kinase pathway inhibitors is paradigmatic of the promise of precision cancer therapy but also highlights problems with drug resistance that limit patient benefit. We use live‐cell imaging, single‐cell analysis, and molecular profiling to show that...

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Bibliographic Details
Main Authors: Mohammad Fallahi‐Sichani, Verena Becker, Benjamin Izar, Gregory J Baker, Jia‐Ren Lin, Sarah A Boswell, Parin Shah, Asaf Rotem, Levi A Garraway, Peter K Sorger
Format: Article
Language:English
Published: Springer Nature 2017-01-01
Series:Molecular Systems Biology
Subjects:
adaptive and reversible drug resistance
BRAFV600E melanomas
de‐differentiated NGFRHigh state
RAF and MEK inhibitors
Online Access:https://doi.org/10.15252/msb.20166796
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https://doi.org/10.15252/msb.20166796

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