Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification

Two-step detection of Lewy body pathology via smell-function testing and CSF α-synuclein seed amplification

Abstract Cerebrospinal fluid (CSF) α-synuclein (α-syn) seed amplification assays (SAAs) can detect Lewy body pathology (LBP) with high accuracy but are invasive and costly. To address these challenges, this study evaluated a two-step workflow combining prescreening via smell-function testing with co...

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Main Authors: Sophie E. Mastenbroek, Lyduine E. Collij, Jacob W. Vogel, Serena Caldera, Geidy E. Serrano, Charles H. Adler, Claudia Marina Vargiu, Sebastian Palmqvist, Frederik Barkhof, Piero Parchi, Thomas G. Beach, Rik Ossenkoppele, Oskar Hansson
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62458-7
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https://doi.org/10.1038/s41467-025-62458-7

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