The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels
Mucosal membranes with strong variability in their viscoelastic properties line numerous organs and are often targeted by mucoadhesive formulations, e.g., highly swellable hydroxypropylmethylcellulose (HPMC) and slightly cross-linked poly(acrylic acid) (PAA) tablets. Although the factors determining...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004770 |
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| author | Gergely Stankovits Kata Szayly Dorián László Galata János Móczó András Szilágyi Benjámin Gyarmati |
| author_facet | Gergely Stankovits Kata Szayly Dorián László Galata János Móczó András Szilágyi Benjámin Gyarmati |
| author_sort | Gergely Stankovits |
| collection | DOAJ |
| description | Mucosal membranes with strong variability in their viscoelastic properties line numerous organs and are often targeted by mucoadhesive formulations, e.g., highly swellable hydroxypropylmethylcellulose (HPMC) and slightly cross-linked poly(acrylic acid) (PAA) tablets. Although the factors determining the strength of mucoadhesion are hierarchical and affected by both reversible and irreversible processes, the currently available strategies generally view mucoadhesion as the individual performance of the mucoadhesive excipient. We propose an integrated concept that considers the viscoelasticity and tensile properties of both the adhesive interphase and the bulk phases. To reduce the complexity of the mucosal membrane and eliminate the effect of specific macromolecular interactions, we studied the adhesion on mucosa-mimetic freeze/thawed (FT) poly(vinyl alcohol) (PVA) hydrogels. Their viscoelastic properties were controlled by the number of FT cycles and the polymer concentration. The adhesive strength of HPMC tablets displayed a pronounced dependence on the viscoelasticity of PVA gels, explained by the limited chain flexibility and interpenetration of HPMC, resulting in the formation of a thin the adhesive interphase compared to PAA. We recognized scaling laws between toughness and strength for tensile and adhesive properties as well as general correlations between viscoelastic and adhesive properties, which can aid the more rational design of both mucoadhesive formulations and mucosa-mimetic materials. |
| format | Article |
| id | doaj-art-0e33b81b5dbe4bf285773550e43566c9 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-0e33b81b5dbe4bf285773550e43566c92025-01-17T04:52:09ZengElsevierMaterials Today Bio2590-00642025-02-0130101416The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogelsGergely Stankovits0Kata Szayly1Dorián László Galata2János Móczó3András Szilágyi4Benjámin Gyarmati5Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, HungaryDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, HungaryDepartment of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, HungaryDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, HUN-REN, Magyar Tudósok Körútja 2., H-1117, Budapest, HungaryDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, HungaryDepartment of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., H-1111, Budapest, Hungary; Corresponding author.Mucosal membranes with strong variability in their viscoelastic properties line numerous organs and are often targeted by mucoadhesive formulations, e.g., highly swellable hydroxypropylmethylcellulose (HPMC) and slightly cross-linked poly(acrylic acid) (PAA) tablets. Although the factors determining the strength of mucoadhesion are hierarchical and affected by both reversible and irreversible processes, the currently available strategies generally view mucoadhesion as the individual performance of the mucoadhesive excipient. We propose an integrated concept that considers the viscoelasticity and tensile properties of both the adhesive interphase and the bulk phases. To reduce the complexity of the mucosal membrane and eliminate the effect of specific macromolecular interactions, we studied the adhesion on mucosa-mimetic freeze/thawed (FT) poly(vinyl alcohol) (PVA) hydrogels. Their viscoelastic properties were controlled by the number of FT cycles and the polymer concentration. The adhesive strength of HPMC tablets displayed a pronounced dependence on the viscoelasticity of PVA gels, explained by the limited chain flexibility and interpenetration of HPMC, resulting in the formation of a thin the adhesive interphase compared to PAA. We recognized scaling laws between toughness and strength for tensile and adhesive properties as well as general correlations between viscoelastic and adhesive properties, which can aid the more rational design of both mucoadhesive formulations and mucosa-mimetic materials.http://www.sciencedirect.com/science/article/pii/S2590006424004770Soft materialsOscillatory shear rheologyRelaxation time spectraChain entanglementsChain flexibilityCohesive failure |
| spellingShingle | Gergely Stankovits Kata Szayly Dorián László Galata János Móczó András Szilágyi Benjámin Gyarmati The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels Materials Today Bio Soft materials Oscillatory shear rheology Relaxation time spectra Chain entanglements Chain flexibility Cohesive failure |
| title | The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| title_full | The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| title_fullStr | The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| title_full_unstemmed | The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| title_short | The adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| title_sort | adhesion mechanism of mucoadhesive tablets with dissimilar chain flexibility on viscoelastic hydrogels |
| topic | Soft materials Oscillatory shear rheology Relaxation time spectra Chain entanglements Chain flexibility Cohesive failure |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004770 |
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