An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells

An integral membrane constitutively active heparanase enhances the tumor infiltration capability of NK cells

Eradication of cancer cells by the immune system requires extravasation, infiltration and progression of immune cells through the tumor extracellular matrix (ECM). These are also critical determinants for successful adoptive cell immunotherapy of solid tumors. Together with structural proteins, such...

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Bibliographic Details
Main Authors: Sofia Liborio-Ramos, Isaac Quiros-Fernandez, Neta Ilan, Soaad Soboh, Malik Farhoud, Ruken Süleymanoglu, Michele Bennek, Sara Calleja-Vara, Martin Müller, Israel Vlodavsky, Angel Cid-Arregui
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Adoptive cell transfer
CAR
cell therapy
chimeric antigen receptor
heparanase
immunotherapy
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2437917
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https://www.tandfonline.com/doi/10.1080/2162402X.2024.2437917

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