Prevalence and outcomes of a pilot definition of severe refractory systemic lupus erythematosus: observations from a multinational Asia-Pacific cohort

Prevalence and outcomes of a pilot definition of severe refractory systemic lupus erythematosus: observations from a multinational Asia-Pacific cohort

Abstract Background Emerging therapies have the potential to be used in patients with severe refractory systemic lupus erythematosus (srSLE), but no agreed definition of srSLE exists. We evaluated a pilot srSLE definition to assess whether a set of disease activity and treatment thresholds could ide...

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Main Authors: Rangi Kandane-Rathnayake, Worawit Louthrenoo, CS Lau, Laniyati Hamijoyo, Jiacai Cho, Aisha Lateef, Shue Fen Luo, Yeong-Jian Wu, Sandra Navarra, Leonid Zamora, Zhanguo Li, Yi-Hsing Chen, Shereen Oon, Madelynn Chan, Sargunan Sockalingam, Yanjie Hao, Zhuoli Zhang, Sang-Cheol Bae, Jun Kikuchi, Tsutomu Takeuchi, Yasuhiro Katsumata, BMDB Basnayake, Fiona Goldblatt, Sean O’Neill, Kristine Pek Ling Ng, Nicola Tugnet, Mark Sapsford, Yih Jia Poh, Cherica Tee, Michael Tee, Naoaki Ohkubo, Adrienne O’Donnell Lefeber, Tamas Shisha, Yoshiya Tanaka, Vera Golder, Mandana Nikpour, Alberta Hoi, Peter Gergely, Eric Morand
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Arthritis Research & Therapy
Subjects:
Systemic lupus erythematosus (SLE)
Severe refractory disease
Poor outcomes
Online Access:https://doi.org/10.1186/s13075-025-03622-8
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https://doi.org/10.1186/s13075-025-03622-8

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