THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION

THE JAK2V617F POINT MUTATION INCREASES THE OSTEOCLAST FORMING ABILITY OF MONOCYTES IN PATIENTS WITH CHRONIC MYELOPROLIFERATIVE NEOPLASMS AND MAKES THEIR OSTEOCLASTS MORE SUSCEPTIBLE TO JAK2 INHIBITION

JAK2V617F is a gain of function point mutation that occurs in Myeloproliferative Neoplasm (MPN) patients and deranges their hemopoiesis at cellular level. We speculate that hyperfunctioning JAK2 can modify osteoclast (OCL) homeostasis in MPN patients. We studied 18 newly diagnosed MPN patients and f...

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Bibliographic Details
Main Authors: Emmanouil Spanoudakis, Menelaos Papoutselis, Ioanna Bazntiara, Eleftheria Lamprianidou, Xrisa Kordella, Constantinos Tilkeridis, Constantinos Tsatalas, Ioannis Kotsianidis
Format: Article
Language:English
Published: PAGEPress Publications 2018-10-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
JAK2V617F
Osteoclast
Myeloproliferative Neoplasm
Online Access:https://www.mjhid.org/index.php/mjhid/article/view/3375
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https://www.mjhid.org/index.php/mjhid/article/view/3375

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