A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model

A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model

Abstract Neural stem cells (NSCs) of the ventricular-subventricular zone (V-SVZ) generate diverse cell types including striatal glia during the neonatal period. NSC progeny uncouple stem cell-related mRNA transcripts from being translated during differentiation. We previously demonstrated that Tsc2...

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Bibliographic Details
Main Authors: Sulagna Mukherjee, Matthew J. Wolan, Mary K. Scott, Victoria A. Riley, Aidan M. Sokolov, David M. Feliciano
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Tsc2
Tuberous sclerosis complex
TSC
SEGA
Subependymal giant cell Astrocytoma
Subependymal nodule
Online Access:https://doi.org/10.1038/s41598-025-08345-z
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https://doi.org/10.1038/s41598-025-08345-z

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