Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein functions

Abstract Protein lactylation is an emerging field. To advance the exploration of its biological functions, here we develop a comprehensive workflow that integrates proteomics to identify lactylated sites, genetic code expansion (GCE) for the expression of site-specifically lactylated proteins in liv...

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Main Authors: Chang Shao, Shuo Tang, Siqin Yu, Chenguang Liu, Yueyang Zhang, Tianyan Wan, Zimeng He, Qi Yuan, Shihan Wu, Hanqing Zhang, Ning Wan, Mengru Zhan, Ren Xiang Tan, Haiping Hao, Hui Ye, Nanxi Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55165-2
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