Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction.

Transcriptome profiling of L. infantum-infected human macrophages reveals sex-specific type I interferon induction.

Sex-based differences in the immune system influence the clinical course of infectious diseases, including many parasitic infections. Field studies of human infections and controlled experimental rodent models have shown that certain clinical forms of leishmaniasis occur more frequently in males. Le...

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Main Authors: Annika Bea, Helena Fehling, Fabian Hausmann, Fahten Margot Habib, Melanie Lütkemeyer, Lara Buer, Carola Schäfer, Charlotte Sophie Hansen, Barbara Honecker, Stefan Bonn, Bianca Elisabeth Schneider, Joachim Clos, Hanna Lotter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013427
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https://doi.org/10.1371/journal.ppat.1013427

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