Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies

Disruption of ZC3H15 compromises telomere length maintenance by entrapping telomerase within cajal bodies

Abstract Background Telomere homeostasis is pivotal in various biological processes including ontogeny, reproduction, physiological aging, and the onset of numerous diseases such as tumors. In human stem cells and approximately 85% of tumor cells, telomerase formed by TERT and TERC RNA complex is re...

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Bibliographic Details
Main Authors: Chuanle Wang, Wei Chen, Ruofei Li, Yue Yang, Jiali Wu, Yuyang Tian, Zibin He, Song Lin, Xining Wang, Jianxi Zhu, Wenbin Ma, Zhou Songyang, Yan Huang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell & Bioscience
Subjects:
ZC3H15
Telomerase
Cajal bodies
Cell senescence
Online Access:https://doi.org/10.1186/s13578-025-01449-z
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https://doi.org/10.1186/s13578-025-01449-z

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