Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women

Whole exome sequencing identifies FANCM as a susceptibility gene for estrogen-receptor-negative breast cancer in Hispanic/Latina women

Abstract Breast cancer (BC) is one of the most common cancers globally. Genetic testing facilitates screening and informs targeted risk-reduction and treatments. However, genes included in testing panels are from European-ancestry studies. We conducted a pooled case-control analysis in self-identifi...

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Main Authors: Jovia L. Nierenberg, Aaron W. Adamson, Donglei Hu, Scott Huntsman, Carmina Patrick, Min Li, Linda Steele, Shu Tao, Yuan Chun Ding, Barry Tong, Yiwey Shieh, Laura Fejerman, Stephen B. Gruber, Christopher A. Haiman, Esther M. John, Lawrence H. Kushi, Gabriela Torres-Mejía, Charité Ricker, Jeffrey N. Weitzel, Elad Ziv, Susan L. Neuhausen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60564-0
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https://doi.org/10.1038/s41467-025-60564-0

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