Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing
Primary hepatic leiomyosarcoma is a rare hepatic malignancy which requires exclusion of other primary site of origin. Clinical presentation and imaging of this tumor is nonspecific and mimics many other hepatic neoplasms. A 62-year-old female patient presents here with right hepatic mass with insidi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_735_22 |
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| author | Ranajoy Ghosh Aniket Halder Ranjit K. Nim Sukanta Ray Uttara Chatterjee |
| author_facet | Ranajoy Ghosh Aniket Halder Ranjit K. Nim Sukanta Ray Uttara Chatterjee |
| author_sort | Ranajoy Ghosh |
| collection | DOAJ |
| description | Primary hepatic leiomyosarcoma is a rare hepatic malignancy which requires exclusion of other primary site of origin. Clinical presentation and imaging of this tumor is nonspecific and mimics many other hepatic neoplasms. A 62-year-old female patient presents here with right hepatic mass with insidious onset and radiological features favoring a benign solid lesion suggestive of focal nodular hyperplasia. On right hepatectomy, an encapsulated mass identified about 11 cm in maximum dimension with pushing margin and central scar-like area. Histopathological examination reveals a spindle cell tumor and panel of immunohistochemical markers is required to distinguish it from other morphological mimickers. Diagnosis of primary hepatic leiomyosarcoma requires histopathology along with immunohistochemical examination. It is thus advisable to do preoperative biopsy with immunohistochemistry in all patients having atypical imaging and clinical features. |
| format | Article |
| id | doaj-art-0cfba3d7aefb4b23ac46d51e3eafd65f |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-0cfba3d7aefb4b23ac46d51e3eafd65f2025-01-10T10:28:18ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167492192310.4103/ijpm.ijpm_735_22Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothingRanajoy GhoshAniket HalderRanjit K. NimSukanta RayUttara ChatterjeePrimary hepatic leiomyosarcoma is a rare hepatic malignancy which requires exclusion of other primary site of origin. Clinical presentation and imaging of this tumor is nonspecific and mimics many other hepatic neoplasms. A 62-year-old female patient presents here with right hepatic mass with insidious onset and radiological features favoring a benign solid lesion suggestive of focal nodular hyperplasia. On right hepatectomy, an encapsulated mass identified about 11 cm in maximum dimension with pushing margin and central scar-like area. Histopathological examination reveals a spindle cell tumor and panel of immunohistochemical markers is required to distinguish it from other morphological mimickers. Diagnosis of primary hepatic leiomyosarcoma requires histopathology along with immunohistochemical examination. It is thus advisable to do preoperative biopsy with immunohistochemistry in all patients having atypical imaging and clinical features.https://journals.lww.com/10.4103/ijpm.ijpm_735_22immunohistochemistryleiomyosarcomaliver neoplasmsmooth muscle actinvimentin |
| spellingShingle | Ranajoy Ghosh Aniket Halder Ranjit K. Nim Sukanta Ray Uttara Chatterjee Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing Indian Journal of Pathology and Microbiology immunohistochemistry leiomyosarcoma liver neoplasm smooth muscle actin vimentin |
| title | Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing |
| title_full | Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing |
| title_fullStr | Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing |
| title_full_unstemmed | Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing |
| title_short | Primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver: A wolf in sheep’s clothing |
| title_sort | primary hepatic leiomyosarcoma masquerading as focal nodular hyperplasia of liver a wolf in sheep s clothing |
| topic | immunohistochemistry leiomyosarcoma liver neoplasm smooth muscle actin vimentin |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_735_22 |
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