Personalizing neoadjuvant chemotherapy regimens for triple-negative breast cancer using a biology-based digital twin

Abstract Despite advances triple negative breast cancer treatment, ~50% of patients will not achieve a pathological complete response prior to surgery with standard of care neoadjuvant therapy (NAT). We hypothesize that personalized regimens for NAT could significantly improve patient outcomes, whic...

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Bibliographic Details
Main Authors: Chase Christenson, Chengyue Wu, David A. Hormuth, Jingfei Ma, Clinton Yam, Gaiane M. Rauch, Thomas E. Yankeelov
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00531-z
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