Does a biological invasion modify host immune responses to parasite infection?
Biological invasions can disrupt the close and longstanding coevolved relationships between host and parasites. At the same time, the shifting selective forces acting on demography during invasion can result in rapid evolution of traits in both host and parasite. Hosts at the invasion front may redu...
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The Royal Society
2025-01-01
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| Series: | Royal Society Open Science |
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| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsos.240669 |
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| author | Gregory P. Brown Richard Shine Lee A. Rollins |
| author_facet | Gregory P. Brown Richard Shine Lee A. Rollins |
| author_sort | Gregory P. Brown |
| collection | DOAJ |
| description | Biological invasions can disrupt the close and longstanding coevolved relationships between host and parasites. At the same time, the shifting selective forces acting on demography during invasion can result in rapid evolution of traits in both host and parasite. Hosts at the invasion front may reduce investment into costly immune defences and redistribute those resources to other fitness-enhancing traits. Parasites at the invasion front may have reduced pathogenicity because traits that negatively impact host dispersal are left behind in the expanding range. The host’s immune system is its primary arsenal in the coevolutionary ‘arms race’ with parasites. To assess the effects of invasion history on immune responses to parasite infection, we conducted a cross-infection experiment which paired common-garden reared cane toads and lungworm parasites originating from various sites in their invaded range across northern Australia. Infected toads had larger spleens and higher concentrations of eosinophils than did uninfected toads. Infected toads also exhibited lower bacteria-killing ability, perhaps reflecting a trade-off of resources towards defences that are more specifically anthelminthic. The impact of infection intensity on multiple immune measures differed among toads and parasites from different parts of the invasion trajectory, supporting the hypothesis that invasion has disrupted patterns of local adaptation. |
| format | Article |
| id | doaj-art-0cd35f1744f84f42a33f4f4725beea8a |
| institution | Kabale University |
| issn | 2054-5703 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | The Royal Society |
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| spelling | doaj-art-0cd35f1744f84f42a33f4f4725beea8a2025-01-15T00:06:00ZengThe Royal SocietyRoyal Society Open Science2054-57032025-01-0112110.1098/rsos.240669Does a biological invasion modify host immune responses to parasite infection?Gregory P. Brown0Richard Shine1Lee A. Rollins2School of Natural Sciences, Macquarie University, Sydney, NSW 2109, AustraliaSchool of Natural Sciences, Macquarie University, Sydney, NSW 2109, AustraliaEvolution & Ecology Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaBiological invasions can disrupt the close and longstanding coevolved relationships between host and parasites. At the same time, the shifting selective forces acting on demography during invasion can result in rapid evolution of traits in both host and parasite. Hosts at the invasion front may reduce investment into costly immune defences and redistribute those resources to other fitness-enhancing traits. Parasites at the invasion front may have reduced pathogenicity because traits that negatively impact host dispersal are left behind in the expanding range. The host’s immune system is its primary arsenal in the coevolutionary ‘arms race’ with parasites. To assess the effects of invasion history on immune responses to parasite infection, we conducted a cross-infection experiment which paired common-garden reared cane toads and lungworm parasites originating from various sites in their invaded range across northern Australia. Infected toads had larger spleens and higher concentrations of eosinophils than did uninfected toads. Infected toads also exhibited lower bacteria-killing ability, perhaps reflecting a trade-off of resources towards defences that are more specifically anthelminthic. The impact of infection intensity on multiple immune measures differed among toads and parasites from different parts of the invasion trajectory, supporting the hypothesis that invasion has disrupted patterns of local adaptation.https://royalsocietypublishing.org/doi/10.1098/rsos.240669Bufo marinuslocal adaptationecoimmunologyleucocytesphagocytosisbacteria-killing |
| spellingShingle | Gregory P. Brown Richard Shine Lee A. Rollins Does a biological invasion modify host immune responses to parasite infection? Royal Society Open Science Bufo marinus local adaptation ecoimmunology leucocytes phagocytosis bacteria-killing |
| title | Does a biological invasion modify host immune responses to parasite infection? |
| title_full | Does a biological invasion modify host immune responses to parasite infection? |
| title_fullStr | Does a biological invasion modify host immune responses to parasite infection? |
| title_full_unstemmed | Does a biological invasion modify host immune responses to parasite infection? |
| title_short | Does a biological invasion modify host immune responses to parasite infection? |
| title_sort | does a biological invasion modify host immune responses to parasite infection |
| topic | Bufo marinus local adaptation ecoimmunology leucocytes phagocytosis bacteria-killing |
| url | https://royalsocietypublishing.org/doi/10.1098/rsos.240669 |
| work_keys_str_mv | AT gregorypbrown doesabiologicalinvasionmodifyhostimmuneresponsestoparasiteinfection AT richardshine doesabiologicalinvasionmodifyhostimmuneresponsestoparasiteinfection AT leearollins doesabiologicalinvasionmodifyhostimmuneresponsestoparasiteinfection |