A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation

A new split‐luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation

The expense and time required for in vivo reproductive and developmental toxicity studies have driven the development of in vitro alternatives. Here, we used a new in vitro split luciferase‐based assay to screen a library of 177 toxicants for inhibitors of apoptosome formation. The apoptosome contai...

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Bibliographic Details
Main Authors: Amin Tashakor, Mahshid H‐Dehkordi, Enda O'Connell, Sergi Gomez Ganau, Rafael Gozalbes, Leif A. Eriksson, Saman Hosseinkhani, Howard O. Fearnhead
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:FEBS Open Bio
Subjects:
Apaf‐1
apoptosome
pentachlorophenol
reproductive toxicity
screening
split luciferase complementation assay
Online Access:https://doi.org/10.1002/2211-5463.12646
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https://doi.org/10.1002/2211-5463.12646

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