Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens

Gene editing tool-loaded biomimetic cationic vesicles with highly efficient bacterial internalization for in vivo eradication of pathogens

Abstract In the post-COVID-19 era, drug-resistant bacterial infections emerge as one of major death causes, where multidrug-resistant Acinetobacter baumannii (MRAB) and drug-resistant Pseudomonas aeruginosa (DRPA) represent primary pathogens. However, the classical antibiotic strategy currently face...

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Bibliographic Details
Main Authors: Xueli Jia, Bochuan Yuan, Wanmei Wang, Ke Wang, Dandan Ling, Meng Wei, Yadan Hu, Wanting Guo, Ziyuan Chen, Lina Du, Yiguang Jin
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Nanobiotechnology
Subjects:
CRISPR/Cas9 plasmid
Outer membrane vesicle
Cationic lipid
Acinetobacter baumannii
Pseudomonas aeruginosa
Pulmonary infection
Online Access:https://doi.org/10.1186/s12951-024-03065-4
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https://doi.org/10.1186/s12951-024-03065-4

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