Primary and secondary metastatic dissemination: multiple routes to cancer-related death

Primary and secondary metastatic dissemination: multiple routes to cancer-related death

Abstract Metastatic disease accounts for approximately 80% of cancer-related deaths, typically manifesting as single-organ failure mainly through abdominal, cardiovascular, neurological, or respiratory complications. Despite treating thousands of cancer patients daily worldwide, our understanding of...

Full description

Saved in:

Bibliographic Details
Main Authors:	D. Sparrer, R. Blazquez, F. Keil, S. Einhell, F. Lüke, S. Uderhardt, C. Gerner, C.H.R. Wendl, M. Proescholdt, C. Schulz, A. Kandulski, S. Haferkamp, H.J. Schlitt, T. Bäuerle, K. Franze, R. Mayr, M. Rechenmacher, P. Hau, D. Hirsch, D. Heudobler, K. Evert, T. Pukrop
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Molecular Cancer
Subjects:	Metastasis Metastatic dissemination Bio Therapeutic Goals of Cancer Care Model Primary dissemination Secondary dissemination Cancer-directed therapy
Online Access:	https://doi.org/10.1186/s12943-025-02389-5
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Disseminated synovial chondromatosis of the knee treated by open radical synovectomy using staged combined anterior and posterior approaches: a case report
by: Sileshi Serebe Zeleke, et al.
Published: (2025-04-01)

Copaxone in therapy of remittent disseminated sclerosis patients
by: O. A. Kitcherova, et al.
Published: (2008-09-01)

Kabale University Research Agenda 2020-2025
by: Kabale University, et al.
Published: (2022)

High-grade endometrial cancer presents with malignancy-associated disseminated intravascular coagulation: A case report
by: Jennifer Hansen, et al.
Published: (2025-08-01)

"A table was a table was a table" : écriture sous rature in Percival Everett's Erasure
by: Sylvie Bauer
Published: (2016-10-01)

Amiternum Project: Archaeology as Social Development’s Engine
by: Alfonso Forgione
Published: (2023-12-01)

Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting
by: L. Meira, et al.
Published: (2019-11-01)

Clinical and Radiographic Features of Lymphogenous Dissemination in Pulmonary Tuberculosis
by: A. S. Vinokurov, et al.
Published: (2020-09-01)

PET-CT FINDING OF BENIGN METASTASIZING LEIOMYOMA
by: A. S. Subbotin, et al.
Published: (2017-03-01)

Disseminated tuberculosis masquerading primary myelodysplastic syndrome
by: Syahrul Sazliyana Shaharir, et al.
Published: (2013-03-01)

The Coagulopathy Bleeding in Disseminated Intravascular Coagulation. Therapy by Heparin and Treatment Plasmapheresis
by: Kurgan M., et al.
Published: (2015-12-01)

Development of approaches for studying the biodistribution of a bicistronic therapeutic plasmid construct in the mouse body
by: S. S. Dzhauari, et al.
Published: (2022-07-01)

Library Website as a Tool for Information Dissemination for Students At Mbarara University Of Science And Technology.
by: Kyomugisha, Adrine
Published: (2024)

New methods for the dissemination of the research on the city: multimedia tools for the sharing of documentary archives
by: Giuseppa Novello, et al.
Published: (2018-12-01)

A CHATBOT FOR POSTGRADUATE INFORMATION DISSEMINATION
by: Umar Emmanuel, et al.
Published: (2025-04-01)

Disseminating the movement behaviour guidelines for young children in Hong Kong: process and outcome evaluations
by: Catherine M. Capio, et al.
Published: (2025-07-01)

A novel perspective on dissemination: somatic metastasis of germ cell tumors from the central nervous system
by: Shao-Pei Qi, et al.
Published: (2025-06-01)

Eruptive Disseminated Spitz Nevi With Architectural Features of Clark/Dysplastic Nevus
by: Giovanna Curi Campos, et al.
Published: (2025-07-01)

Peritoneal dissemination of appendiceal goblet cell adenocarcinoma mimicking white pus caused by peritonitis following appendicitis: an instructive case report
by: Keigo Nakashima, et al.
Published: (2024-02-01)

A Case Report on Disseminated Tuberculosis in a Newborn
by: Sachin Bhagat, et al.
Published: (2023-04-01)

Gluteal muscle metastasis with peritoneal dissemination from gastric cancer during postoperative adjuvant chemotherapy: a case report
by: Shotaro Korehisa, et al.
Published: (2021-02-01)

TRACHEOSTOMY IN THE PATIENT WITH DISSEMINATED INTRAVASCULAR COAGULATION
by: A. V. Schyogolev, et al.
Published: (2017-11-01)

Innovative Activity of School Teacher as Factor of Professional Development within Chosen Profession
by: L. B. Bakhtigulova
Published: (2018-09-01)

Neurosurgical interventions in patients with disseminated solid tumors and poor prognosis
by: V. А. Аlyoshin, et al.
Published: (2018-07-01)

DISEMINASI TEKNOLOGI PEMBUATAN PAKAN BUATAN ALTERNATIF DENGAN CAMPURAN LIMBAH KANGKUNG AIR, IPOMOEA AQUATICA FORKS UNTUK PEMBUDIDAYA IKAN DI SUMATERA BARAT
by: Efrizal Efrizal, et al.
Published: (2018-09-01)

Key Dissemination Learnings from an Innovative, Value-Based Emergency Department Prevention Program
by: Rohie Marshall
Published: (2024-12-01)

A case of disseminated BCG infection in a daughter of Italian immigrants in Switzerland
by: Claudia Colomba, et al.
Published: (2022-02-01)

Clonal spread of bla CTX-M-65 producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA
by: Daniel F. M. Monte, et al.
Published: (2025-07-01)

Correction of the Fibrinolytic Type of the Disseminated Intravascular Coagulation Syndrome in the Early Postoperative Period
by: S. V. Sinkov, et al.
Published: (2007-02-01)

Scaling evidence-based interventions: Examining factors promoting and limiting the dissemination of research mentor training
by: Kimberly Spencer, et al.
Published: (2025-01-01)

Project Development and Participation in Competitions as Strategies for the Development of Employability Skills Required by Knowledge Oriented Sectors
by: Margarita Tecpoyotl Torres, et al.
Published: (2025-08-01)

Breaking confirmatory spells by implementing research-integrated CUREs
by: Jan A. C. Vriezen
Published: (2025-08-01)

Exploring meso- and macro-level contextual factors associated with inequalities in program adoption during statewide scale-up of TransformUs Primary, a whole-school physical activity intervention
by: Elly Ganakas, et al.
Published: (2025-08-01)

Inoculation route-dependent Lassa virus dissemination and shedding dynamics in the natural reservoir – Mastomys natalensis
by: D. M. Wozniak, et al.
Published: (2021-01-01)

Training for Sustainable and Healthy Building for 2050 Part 2: Incorporation of New Knowledge and Dissemination for the Sustainability of the Trans-European Training Experience
by: Susana Lucas, et al.
Published: (2025-04-01)

Tips and Pitfalls in Using Social Media Platforms for Survey Dissemination
by: William Lay Keat Ong, et al.
Published: (2023-03-01)

Experience in treating disseminated breast cancer after multimodality therapy
by: G. A. Khakimov, et al.
Published: (2014-08-01)

Detection of disseminated tumor cells in lymph nodes from patients with early stage non-small cell lung cancer
by: Ane Kongsgaard, et al.
Published: (2016-06-01)

Current standards for the treatment of metastatic breast cancer (According to the proceedings of the International Conference on Breast Cancer, Moscow, January 22–24, 2014)
by: V. P. Letyagin, et al.
Published: (2014-07-01)

Pleural dissemination of epithelioid hemangioendothelioma diagnosed using semi-rigid thoracoscopic pleural cryobiopsy
by: Tomoya Horiguchi, et al.
Published: (2025-01-01)