Ferroptosis exacerbates the clonal deletion of virus-specific exhausted CD8+ T cells

During chronic infection or tumorigenesis, persistent antigen stimulation contributes to the exhaustion of CD8+ T cells. Nevertheless, exhausted CD8+ T (TEX) cells still preserve certain effector function, and maintaining a reservoir of exhausted cells is of vital importance for virus elimination an...

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Bibliographic Details
Main Authors: Qin Tian, Cheng Chen, Jinjin Lu, Xinyu Zheng, Xiuming Zhai, Yanping Yang, Ziyao Zhao, Jiangtao Hao, Ke Yang, Lilin Ye, Yifei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
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Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490845/full
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