Substrate-driven mapping of the degradome by comparison of sequence logos.

Sequence logos are frequently used to illustrate substrate preferences and specificity of proteases. Here, we employed the compiled substrates of the MEROPS database to introduce a novel metric for comparison of protease substrate preferences. The constructed similarity matrix of 62 proteases can be...

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Bibliographic Details
Main Authors: Julian E Fuchs, Susanne von Grafenstein, Roland G Huber, Christian Kramer, Klaus R Liedl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1003353
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