Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Targeting glutamine synthetase with AS1411-modified exosome-liposome hybrid nanoparticles for inhibition of choroidal neovascularization

Abstract Choroidal neovascularization (CNV) is a leading cause of visual impairment in wet age-related macular degeneration (wAMD). Recent investigations have validated the potential of reducing glutamine synthetase (GS) to inhibit neovascularization formation, offering prospects for treating variou...

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Bibliographic Details
Main Authors: Miaomiao Zhang, Xinyue Lu, Lifu Luo, Jinqiu Dou, Jingbo Zhang, Ge Li, Li Zhao, Fengying Sun
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Nanobiotechnology
Subjects:
CRISPR/Cas9
Choroidal neovascularization
Exosome
Liposome
Glutamine synthetase
Age-related macular degeneration
Online Access:https://doi.org/10.1186/s12951-024-02943-1
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