Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion
Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily p...
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Elsevier
2025-02-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424004927 |
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| author | Xinran Yang Xiudan Wang Lizong Tang Zhiguang Sun Xing Gao Yanmei Zhao Shike Hou Jie Shi Qi Lv |
| author_facet | Xinran Yang Xiudan Wang Lizong Tang Zhiguang Sun Xing Gao Yanmei Zhao Shike Hou Jie Shi Qi Lv |
| author_sort | Xinran Yang |
| collection | DOAJ |
| description | Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily precipitate tissue adhesion in vivo and other complications. Based on the anti-protein properties of zwitterion and our previous work about in situ hemostatic/anti-adhesion hydrogel material, we have synthesized a series of injectable hydrogel composed of sulfobetaine-modified polylactic acid (PLA) and gelatin (Gel). These hydrogels could form a smooth film structure by simple water triggering, thereby conferring anti-adhesive properties. We visualized the changes in surface hydrophobicity using fluorescent probes and demonstrated tissue adhesion, rapid hydrophobic interface response, as well as rapid hemostasis for incompressible wounds through in vivo and in vitro experiments. Additionally, we explored the application of hydrogel materials in the scenario of postoperative bleeding, which can effectively prevent unnecessary adhesion through rapid film formation and the anti-protein property of sulfobetaine. We believe that this multifunctional hemostatic hydrogel has the potential to serve as a prehospital emergency treatment of incompressible bleeding and benefit to the postoperative recovery of patients. |
| format | Article |
| id | doaj-art-0c3ffff830b1405a9efe39f81c2ffe0d |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-0c3ffff830b1405a9efe39f81c2ffe0d2025-01-17T04:52:12ZengElsevierMaterials Today Bio2590-00642025-02-0130101431Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesionXinran Yang0Xiudan Wang1Lizong Tang2Zhiguang Sun3Xing Gao4Yanmei Zhao5Shike Hou6Jie Shi7Qi Lv8Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Tianjin Hospital, Tianjin University, Tianjin, 300072, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, ChinaInstitution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, China; Corresponding author. Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China.Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, China; Corresponding author. Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China.Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China; Key Laboratory for Disaster Medicine Technology, Tianjin, 300072, China; Wenzhou Safety (Emergency) Institute of Tianjin University, Wenzhou, 325026, China; Corresponding author. Institution of Disaster and Emergency Medicine, Tianjin University, Tianjin, 300072, China.Massive blood loss is the main cause of prehospital trauma-related death, the development of rapid and effective hemostatic materials is imminent. Injectable hydrogels have the advantages of covering irregular bleeding sites and quickly closing the wound. However, its inherent viscosity can easily precipitate tissue adhesion in vivo and other complications. Based on the anti-protein properties of zwitterion and our previous work about in situ hemostatic/anti-adhesion hydrogel material, we have synthesized a series of injectable hydrogel composed of sulfobetaine-modified polylactic acid (PLA) and gelatin (Gel). These hydrogels could form a smooth film structure by simple water triggering, thereby conferring anti-adhesive properties. We visualized the changes in surface hydrophobicity using fluorescent probes and demonstrated tissue adhesion, rapid hydrophobic interface response, as well as rapid hemostasis for incompressible wounds through in vivo and in vitro experiments. Additionally, we explored the application of hydrogel materials in the scenario of postoperative bleeding, which can effectively prevent unnecessary adhesion through rapid film formation and the anti-protein property of sulfobetaine. We believe that this multifunctional hemostatic hydrogel has the potential to serve as a prehospital emergency treatment of incompressible bleeding and benefit to the postoperative recovery of patients.http://www.sciencedirect.com/science/article/pii/S2590006424004927Injectable hydrogelZwitterionAnti-adhesionIncompressible bleedingHemostasis |
| spellingShingle | Xinran Yang Xiudan Wang Lizong Tang Zhiguang Sun Xing Gao Yanmei Zhao Shike Hou Jie Shi Qi Lv Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion Materials Today Bio Injectable hydrogel Zwitterion Anti-adhesion Incompressible bleeding Hemostasis |
| title | Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion |
| title_full | Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion |
| title_fullStr | Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion |
| title_full_unstemmed | Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion |
| title_short | Water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti-adhesion |
| title_sort | water triggered injectable polylactic acid hydrogel based on zwitterionic sulfobetaine modification for incompressible bleeding and tissue anti adhesion |
| topic | Injectable hydrogel Zwitterion Anti-adhesion Incompressible bleeding Hemostasis |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424004927 |
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