Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors

Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors

IntroductionThe paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A2A receptor (A2AR) in the PVT in regulating pain...

Full description

Saved in:
Bibliographic Details
Main Authors: Yiping Cao, Zhou Wu, Moruo Zhang, Ran Ji, Hongxing Zhang, Lingzhen Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
A2A receptor
PVT
microglia
pain sensation
opioid receptor
cannabinoid receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1467305/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1467305/full

Similar Items