Moxifloxacin-induced neutropenia in 26-year-old man
Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case. A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the sec...
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| Format: | Article |
| Language: | English |
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The Journal of Infection in Developing Countries
2018-10-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/10212 |
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| author | Tuğba Kula Atik Emre Ispir Aykut Aytekin Ufuk Turhan Esma Yeniiz Dilaver Tas Orhan Bedir |
| author_facet | Tuğba Kula Atik Emre Ispir Aykut Aytekin Ufuk Turhan Esma Yeniiz Dilaver Tas Orhan Bedir |
| author_sort | Tuğba Kula Atik |
| collection | DOAJ |
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Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case.
A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the second day of therapy, leukopenia [White blood cell (WBC) count 2.7×10³/μL] and neutropenia (neutrophils 1.21×10³/μL) occurred. Rothia mucilaginosa was isolated in sputum culture. On the fourth day of hospitalization moxifloxacin treatment was stopped and clarithromycin 500 mg PO twice daily was started. Leukopenia and neutropenia resolved one day after discontinuation of moxifloxacin that WBC and neutrophil count rose 4.5×10³/μL and 1.97×10³/μL, respectively. On the sixth day of hospitalization, WBC and neutrophil count was 4.3×10³/μL and 2.29×10³/μL, respectively.
The immunomodulatory effects of moxifloxacin may result in the changes of WBC count like leukopenia with neutropenia. Moxifloxacin induced neutropenia may be more common and is an important adverse effect. More observational studies about safety profiles of moxifloxacin are needed.
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| format | Article |
| id | doaj-art-0b51de69f19c48149a3e8570559125d9 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-0b51de69f19c48149a3e8570559125d92025-08-20T03:48:46ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802018-10-01121010.3855/jidc.10212Moxifloxacin-induced neutropenia in 26-year-old manTuğba Kula Atik0Emre Ispir1Aykut Aytekin2Ufuk Turhan3Esma Yeniiz4Dilaver Tas5Orhan Bedir6Balıkesir Atatürk City Hospital, Balıkesir, TurkeyBalıkesir Atatürk City Hospital, Balıkesir, TurkeyBalikesir State Hospital, Balıkesir, TurkeyBalikesir State Hospital, Balıkesir, TurkeyBalikesir State Hospital, Balıkesir, TurkeySultan Abdülhamid Han Training and Research Hospital, Istanbul, TurkeyGülhane Training and Research Hospital, Ankara, Turkey Moxifloxacin is a fourth generation widely used fluoroquinolone antibiotic. There are three cases of moxifloxacin-induced neutropenia reported in the literature and we report the fourth case. A 26-year-old man with pneumonia was treated with moxifloxacin because of penicillin allergy. On the second day of therapy, leukopenia [White blood cell (WBC) count 2.7×10³/μL] and neutropenia (neutrophils 1.21×10³/μL) occurred. Rothia mucilaginosa was isolated in sputum culture. On the fourth day of hospitalization moxifloxacin treatment was stopped and clarithromycin 500 mg PO twice daily was started. Leukopenia and neutropenia resolved one day after discontinuation of moxifloxacin that WBC and neutrophil count rose 4.5×10³/μL and 1.97×10³/μL, respectively. On the sixth day of hospitalization, WBC and neutrophil count was 4.3×10³/μL and 2.29×10³/μL, respectively. The immunomodulatory effects of moxifloxacin may result in the changes of WBC count like leukopenia with neutropenia. Moxifloxacin induced neutropenia may be more common and is an important adverse effect. More observational studies about safety profiles of moxifloxacin are needed. https://jidc.org/index.php/journal/article/view/10212FluoroquinolonemoxifloxacinneutropeniapneumoniaRothia mucilaginosa |
| spellingShingle | Tuğba Kula Atik Emre Ispir Aykut Aytekin Ufuk Turhan Esma Yeniiz Dilaver Tas Orhan Bedir Moxifloxacin-induced neutropenia in 26-year-old man Journal of Infection in Developing Countries Fluoroquinolone moxifloxacin neutropenia pneumonia Rothia mucilaginosa |
| title | Moxifloxacin-induced neutropenia in 26-year-old man |
| title_full | Moxifloxacin-induced neutropenia in 26-year-old man |
| title_fullStr | Moxifloxacin-induced neutropenia in 26-year-old man |
| title_full_unstemmed | Moxifloxacin-induced neutropenia in 26-year-old man |
| title_short | Moxifloxacin-induced neutropenia in 26-year-old man |
| title_sort | moxifloxacin induced neutropenia in 26 year old man |
| topic | Fluoroquinolone moxifloxacin neutropenia pneumonia Rothia mucilaginosa |
| url | https://jidc.org/index.php/journal/article/view/10212 |
| work_keys_str_mv | AT tugbakulaatik moxifloxacininducedneutropeniain26yearoldman AT emreispir moxifloxacininducedneutropeniain26yearoldman AT aykutaytekin moxifloxacininducedneutropeniain26yearoldman AT ufukturhan moxifloxacininducedneutropeniain26yearoldman AT esmayeniiz moxifloxacininducedneutropeniain26yearoldman AT dilavertas moxifloxacininducedneutropeniain26yearoldman AT orhanbedir moxifloxacininducedneutropeniain26yearoldman |