Descart: a method for detecting spatial chromatin accessibility patterns with inter-cellular correlations

Descart: a method for detecting spatial chromatin accessibility patterns with inter-cellular correlations

Abstract Spatial epigenomic technologies enable simultaneous capture of spatial location and chromatin accessibility of cells within tissue slices. Identifying peaks that display spatial variation and cellular heterogeneity is the key analytic task for characterizing the spatial chromatin accessibil...

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Bibliographic Details
Main Authors: Xiaoyang Chen, Keyi Li, Xiaoqing Wu, Zhen Li, Qun Jiang, Xuejian Cui, Zijing Gao, Yanhong Wu, Rui Jiang
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Genome Biology
Subjects:
Spatially variable peak
Spatial ATAC-seq
Feature selection
Inter-cellular correlations
Data imputation
Peak module
Online Access:https://doi.org/10.1186/s13059-024-03458-6
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https://doi.org/10.1186/s13059-024-03458-6

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