CD8+PD-1+ to CD4+PD-1+ ratio (PERLS) is associated with prognosis of patients with advanced NSCLC treated with PD-(L)1 blockers

CD8+PD-1+ to CD4+PD-1+ ratio (PERLS) is associated with prognosis of patients with advanced NSCLC treated with PD-(L)1 blockers

Background Programmed cell death protein-1 (PD-1) expression has been associated with activation and exhaustion of both the CD4 and CD8 populations in advanced non-small cell lung cancer (aNSCLC). Nevertheless, the impact of the balance between circulating CD8+PD-1+ and CD4+PD-1+ in patients treated...

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Main Authors: Francois-Xavier Danlos, Aurélien Marabelle, Roberto Ferrara, Benjamin Besse, Lydie Cassard, Nathalie Chaput, Aude Desnoyer, Boris Duchemann, Marie Naigeon, Edouard Auclin, Jean-Mehdi Jouniaux, Lisa Boselli, Jonathan Grivel, Laura Mezquita, Caroline Caramella
Format: Article
Language:English
Published: BMJ Publishing Group 2022-02-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/2/e004012.full
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https://jitc.bmj.com/content/10/2/e004012.full

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