Evaluation of immune checkpoint inhibitor efficacy for solid tumors with CD274 (PD-L1 gene) amplification identified by comprehensive genomic profiling: retrospective study based on a nationwide database

Background Amplification of the programmed cell death-ligand 1 gene (CD274) is highly prevalent and associated with a high response rate to immune checkpoint inhibitors (ICIs) in lymphomas, and is also a potential biomarker for ICI treatment of solid tumors. However, the efficacy of ICIs for solid t...

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Bibliographic Details
Main Authors: Hidetoshi Hayashi, Yasutaka Chiba, Kazuhiko Nakagawa, Tomohiro Nakayama, Kimio Yonesaka, Takayuki Takahama, Hisato Kawakami, Naoki Shiraishi
Format: Article
Language:English
Published: BMJ Publishing Group 2024-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/12/12/e010130.full
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