Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure

Macrophage DGKζ-mediated phosphatidic acid remodeling aggravates acute liver failure

Acute liver failure (ALF) is a life-threatening condition associated with macrophage-mediated inflammatory responses. Effective therapies and drugs are still lacking to date. Here, we reveal that a derivative of xanthohumol, CAM12203, alleviates lipopolysaccharide (LPS) + d-galactosamine (D-GalN)-in...

Full description

Saved in:
Bibliographic Details
Main Authors: Yumeng Miao, Tzuchun Lin, Bianlin Wang, Junyu Xu, Chongxian Li, Zuopeng Li, Xinwen Zhang, Chendong Zhou, Tuerganaili Aji, Minjia Tan, Haji Akber Aisa, Jingya Li
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Xanthohumol derivative
Macrophages
Acute liver failure
Diacylglycerol kinase ζ
Phosphatidic acid
Signal transducer and activator of transcription 3
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525004393
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2211383525004393

Similar Items