Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer

Small molecule disruption of RARα/NCoR1 interaction inhibits chaperone-mediated autophagy in cancer

Abstract Chaperone-mediated autophagy (CMA), a type of selective degradation of cytosolic proteins in lysosomes, is commonly upregulated in cancer cells, contributing to their survival and growth. The lack of a specific target for CMA inhibition has limited CMA blockage to genetic manipulations or g...

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Main Authors: Mericka McCabe, Rajanya Bhattacharyya, Rebecca Sereda, Olaya Santiago-Fernández, Rabia R Khawaja, Antonio Diaz, Kristen Lindenau, Deniz Gulfem Ozturk, Thomas P Garner, Simone Sidoli, Ana Maria Cuervo, Evripidis Gavathiotis
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:EMBO Molecular Medicine
Subjects:
Autophagy
CMA Inhibitor
NCoR1
Non-small Cell Lung Cancer
RARα
Online Access:https://doi.org/10.1038/s44321-025-00254-y
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https://doi.org/10.1038/s44321-025-00254-y

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