CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix

CD73 alleviates osteoarthritis by maintaining anabolism and suppressing catabolism of chondrocytes extracellular matrix

Background: Osteoarthritis (OA) is the most common degenerative joint disease, with articular cartilage degeneration as primary manifestation. Intra-articular injection of exogenous liposomal adenosine in mice knee has been shown to alleviate OA progression. However, the role of CD73, the rate-limit...

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Main Authors: Hu Guo, Zhongyang Lv, Maochun Wang, Weitong Li, Ya Xie, Zizheng Liu, Fufei Chen, Ruiyang Jiang, Yuan Liu, Rui Wu, Jiawei Li, Ziying Sun, Guihua Tan, Dongquan Shi
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Adenosine
CD73
Chondrocytes extracellular matrix
Osteoarthritis
Single nucleotide polymorphisms
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24001013
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