CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability

CX26 promotes pancreatic cancer progression by competitively inhibiting interaction of c-Myc with PSMD2 and enhancing c-Myc stability

Abstract Background Pancreatic cancer (PC) is highly aggressive and fatal and has dismal prognostic outcomes, primarily due to its late-stage diagnosis and limited effective treatments. The molecular mechanisms triggering PC progression are largely unclear. This study investigated how CX26 contribut...

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Bibliographic Details
Main Authors: Cheng He, Chuanyu Tang, Jie Guo, Xiangyi Yin, Qing Zhu, Chihua Fang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic cancer
CX26
c-Myc
PSMD2
Proteasomal degradation
Online Access:https://doi.org/10.1186/s12967-025-06983-5
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