Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)

Synthesis and biochemical evaluation of new 3-amido-4-substituted monocyclic ß-lactams as inhibitors of penicillin-binding protein(s)

In the final phases of bacterial cell wall synthesis, penicillin-binding proteins (PBPs) catalyze the cross-linking of peptidoglycan. For many decades, effective and non-toxic β-lactam antibiotics have been successfully used as mimetics of the d-Ala-d-Ala moiety of the natural substrate and employed...

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Main Authors: Grabrijan Katarina, Benedik Nika Strašek, Krajnc Alen, Bozovičar Krištof, Knez Damijan, Proj Matic, Zdovc Irena, Sosič Izidor, Contreras-Martel Carlos, Dessen Andréa, Rambaher Martina Hrast, Gobec Stanislav
Format: Article
Language:English
Published: Sciendo 2024-09-01
Series:Acta Pharmaceutica
Subjects:
antibacterial agents
monocyclic-β-lactams
penicillin-binding proteins
covalent inhibitors
transpeptidase
Online Access:https://doi.org/10.2478/acph-2024-0024
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https://doi.org/10.2478/acph-2024-0024

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