Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence
Abstract Background Dextromethorphan (DXM) is an over‐the‐counter drug that is commonly abused by teenagers. Its main pharmacological property is a low‐affinity N‐methyl‐d‐aspartate (NMDA) receptor antagonist. Case Presentation We report acute psychotic dissociation induced by DXM and alcohol in a p...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | PCN Reports |
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| Online Access: | https://doi.org/10.1002/pcn5.70011 |
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| author | Yasuhito Nagai Yuko Tajima Koichi Miyakawa |
| author_facet | Yasuhito Nagai Yuko Tajima Koichi Miyakawa |
| author_sort | Yasuhito Nagai |
| collection | DOAJ |
| description | Abstract Background Dextromethorphan (DXM) is an over‐the‐counter drug that is commonly abused by teenagers. Its main pharmacological property is a low‐affinity N‐methyl‐d‐aspartate (NMDA) receptor antagonist. Case Presentation We report acute psychotic dissociation induced by DXM and alcohol in a patient with alcohol dependence, which made it difficult to distinguish alcohol withdrawal symptoms with limited information. The psychotic symptoms were ameliorated by haloperidol; however, in cases of DXM abuse, haloperidol treatment should be avoided. Conclusion In the consultation of patients with addiction, the possibility of various addictive drugs must be kept in mind. The concomitant use of DXM and alcohol causes easy dissociation and high‐dose usage of DXM and alcohol withdrawal symptoms are difficult to distinguish. |
| format | Article |
| id | doaj-art-0a37256abb954342a25acb1c243a035b |
| institution | Kabale University |
| issn | 2769-2558 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj-art-0a37256abb954342a25acb1c243a035b2025-01-03T11:15:26ZengWileyPCN Reports2769-25582024-12-0134n/an/a10.1002/pcn5.70011Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependenceYasuhito Nagai0Yuko Tajima1Koichi Miyakawa2Department of Psychiatry Juntendo University Graduate School of Medicine Tokyo JapanDepartment of Psychiatry Juntendo University Urayasu Hospital Urayasu JapanDepartment of Psychiatry Juntendo University Graduate School of Medicine Tokyo JapanAbstract Background Dextromethorphan (DXM) is an over‐the‐counter drug that is commonly abused by teenagers. Its main pharmacological property is a low‐affinity N‐methyl‐d‐aspartate (NMDA) receptor antagonist. Case Presentation We report acute psychotic dissociation induced by DXM and alcohol in a patient with alcohol dependence, which made it difficult to distinguish alcohol withdrawal symptoms with limited information. The psychotic symptoms were ameliorated by haloperidol; however, in cases of DXM abuse, haloperidol treatment should be avoided. Conclusion In the consultation of patients with addiction, the possibility of various addictive drugs must be kept in mind. The concomitant use of DXM and alcohol causes easy dissociation and high‐dose usage of DXM and alcohol withdrawal symptoms are difficult to distinguish.https://doi.org/10.1002/pcn5.70011alcohol dependencedextromethorphanover‐the‐counter (OTC) drug |
| spellingShingle | Yasuhito Nagai Yuko Tajima Koichi Miyakawa Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence PCN Reports alcohol dependence dextromethorphan over‐the‐counter (OTC) drug |
| title | Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence |
| title_full | Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence |
| title_fullStr | Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence |
| title_full_unstemmed | Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence |
| title_short | Concomitant use of dextromethorphan and alcohol‐induced dissociation in a patient with alcohol dependence |
| title_sort | concomitant use of dextromethorphan and alcohol induced dissociation in a patient with alcohol dependence |
| topic | alcohol dependence dextromethorphan over‐the‐counter (OTC) drug |
| url | https://doi.org/10.1002/pcn5.70011 |
| work_keys_str_mv | AT yasuhitonagai concomitantuseofdextromethorphanandalcoholinduceddissociationinapatientwithalcoholdependence AT yukotajima concomitantuseofdextromethorphanandalcoholinduceddissociationinapatientwithalcoholdependence AT koichimiyakawa concomitantuseofdextromethorphanandalcoholinduceddissociationinapatientwithalcoholdependence |