Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Mesenchymal Stromal Cell Secretome and Its Key Bioactive Metabolites Induce Long‐Term Neuroprotection After Traumatic Brain Injury in Mice

Abstract The severe and long‐term consequences of traumatic brain injury (TBI) highlight the urgent need for effective neuroprotective therapies. Mesenchymal stromal cells (MSCs) show promise in TBI treatment through their secretome (conditioned media, CM). A low‐molecular‐weight (<700 Da) CM fra...

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Main Authors: Francesca Pischiutta, Francesca Tribuzio, Marta Magatti, Giulia De Simone, Federico Moro, Giovanni Nattino, Fabiola Signorini, Luther Loose, Enrico Caruso, Costanza Bertani, Edoardo Mazzone, Rosaria Pascente, Edoardo Micotti, Antonietta Rosa Silini, Fabrizio Ortolano, Maria Chiara Trolese, Marco Bolis, Luca Guarrera, Martina Bruna Violatto, Paolo Bigini, Cristina Banfi, Roberta Pastorelli, Ornella Parolini, Laura Brunelli, Elisa R Zanier
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
immunomodulation
mesenchymal stromal cells
metabolomics
neuroprotection
secretome
traumatic brain injury
Online Access:https://doi.org/10.1002/advs.202415508
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https://doi.org/10.1002/advs.202415508

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