Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques

Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques

Abstract Marmosets and macaques are common nonhuman primate models of cognition, yet marmosets appear more distractible and perform worse in cognitive tasks. The dorsolateral prefrontal cortex (dlPFC) is pivotal for sustained attention, and research in macaques suggests that dopaminergic modulation...

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Main Authors: Mary Kate P. Joyce, Tsvetoslav G. Ivanov, Fenna M. Krienen, Jude F. Mitchell, Shaojie Ma, Wataru Inoue, Anirvan S. Nandy, Dibyadeep Datta, Alvaro Duque, Jon I. Arellano, Rahul Gupta, Guillermo Gonzalez-Burgos, David A. Lewis, Nenad Sestan, Steven A. McCarroll, Julio Martinez-Trujillo, Seán Froudist-Walsh, Amy F. T. Arnsten
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08297-0
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